Can cyclobenzaprine help with tooth pain?  

Can cyclobenzaprine help with tooth pain

Tooth pain can be very distressing and adversely affect your daily activities. The throbbing pain from the tooth doesn’t relieve unless you take a medicine. At this point, you may get confused whether cyclobenzaprine can help you get rid of toothache. In this article, I’m going to answer your question, if cyclobenzaprine help with tooth pain.

Before answering the question, I’d like you first to understand what cyclobenzaprine is and how it works so that you can understand things better. 

What is cyclobenzaprine?

Cyclobenzaprine is a muscle relaxant that is used to relieve chronic muscle spasms. It is available in pharmacies under Armix, Flexeril,  flexmid, FusePaq Tabradol, and FlaxePax kit.

Cyclobenzaprine dosage: It is available in the following dosages:

  • Cyclobenzaprine 5 mg is given in elderly patients to keep the dosage low to avoid its side effects
  • Cyclobenzaprine 10 mg is prescribed three times a day. 

Cyclobenzaprine is used to treat pain due to following disorders: 

This muscle relaxer also decreases stress or anxiety following an injury or accident and improves sleep, and calms the nerves. 

How does cyclobenzaprine work?

Cyclobenzaprine enters the brain and relaxes the muscles by inhibiting the nerve impulse responsible for muscle contraction. It is given along with rest and physical therapy to relieve muscle spasms. 

Can cyclobenzaprine help with tooth pain?

No, it doesn’t relieve tooth pain. Toothache is inflammatory in origin and occurs due to bacterial invasion on the tooth’s nerves. The body responds to this attack by producing chemical substances that attack the bacteria to wall off the infection. In doing so, these chemical substances cause damage to the body tissues resulting in pain, redness, and swelling (due to fluid accumulation). 

Patients with wisdom tooth infections often experience difficulty in mouth opening due to muscle spasm of muscles of mastication. This muscle spasm is brought about by the inflammation going on at the site of infection. Therefore, the medications that reduce inflammation resolve the pain. The muscle relaxer (cyclobenzaprine) can be used in conjunction with anti-inflammatory medicines, but muscle relaxants alone may not give you any pain relief. 

A study was carried out where cyclobenzaprine was given to the patients following impacted wisdom tooth surgery to alleviate the post-surgical muscle spasm.

The results found no significant difference in pain relief in the patient who used it. 

The study concluded that there is no need to add an additional medicine to the prescription when the anti-inflammatory medicines (described below) relieve the pain before and after the surgery.

Thiago de santana santos.

Why should you avoid cyclobenzaprine?

Cyclobenzaprine side effects: It should be avoided for toothache as it has several side effects. The common side effects are headache, drowsiness, fatigue, blurred vision, and dry mouth. It should never be used for more than two or three weeks and should be avoided in patients with liver disease. 

Cyclobenzaprine addiction: It is prescribed for not longer than two to three weeks due to its addiction potential. 

Cyclobenzaprine interactions: It interacts with other anti-depressants medications (a group known as tricyclic antidepressants) and may lead to a life-threatening reaction. 

When is Cyclobenzaprine not prescribed?

Cyclobenzaprine is not prescribed if you have a 

  • Heart disease 
  • Liver disease 
  • Overactive thyroid 

Muscle relaxants are avoided during pregnancy, but if necessary, cyclobenzaprine can be given as it has been categorized in group B by FDA for drug safety to be used in pregnancy. 

What are safer alternatives to relieve tooth pain?

You can take medications such as panadol, paracetamol, or aspirin instead of cyclobenzaprine for toothache. They resolve inflammation and give you short-term pain relief. However, definitive treatment of toothache involves removal of the source of infection through root canal treatment or extraction of the tooth. 

You may take any of the following medicines for pain relief:

If the pain is not relieved by any one of the above medicines, you can take paracetamol and ibuprofen together. Beware not to take aspirin and ibuprofen together as they belong to the same group and can lead to severe side effects.  

These medicines are comparatively safer and provide temporary relief from toothache. 

Frequnetly asked questions (FAQ’s)

Will a muscle relaxer help with tooth pain?

There is a wide range of muscle relaxers available. The following are the commonly prescribed muscle relaxants:

  • Carisoprodol (Soma)
  • Clorzoxazone (Lorzone)
  • Dantrolene (Dantrium)
  • Metaxalone (Metaxall) 
  • Tizanidine (Comfort Pac)
  • Orphenadrine
  • Methocarbamol (Robaxin)
  • Cyclobenzaprine (armix)

Muscle relaxants should always be taken with a physician’s prescription because they interact with many medicines. It would help if you told your healthcare provider about all the prescription and non-prescription medications you are taking so they advise you accordingly. 

Muscle relaxants may not be effective for a typical toothache due to tooth infection. However, some people experience unusual tooth pain with complex etiologies, for instance, temporomandibular joint (TMJ) disorder (TMJ joint allows opening and closing of jaws) with a cracked tooth. Both problems arise from teeth grinding with spasm of the muscles of mastication. You may complain of a sharp shooting pain on biting particular food and in a specific way. 

Muscle relaxants are often helpful for resolving such painful teeth, but that requires proper evaluation by your dentist. 

Can Flexeril help with tooth pain?

Flexeril contains cyclobenzaprine, but it has now been discontinued in the US (2023) by its manufacturer, Pfizer. The exact reason for the drug discontinuation is not yet known. It could be due to can be due to its declining sales, risk of drug abuse (flexeril high), and the availability of more effective muscle relaxers.

As mentioned, there is no extra advantage of taking a muscle relaxer for tooth infection because it doesn’t add much for relieving pain symptoms, but has loads of long-term advese effects. 

Can you take a muscle relaxer for gum pain?

No, muscle relaxers can’t be taken for gum pain because no muscles are involved in the gum swelling and pain. Gum pain is usually inflammatory in origin and requires anti-inflammatory medications for pain relief. 


The straightforward answer to ‘can cyclobenzaprine help with tooth pain’ is it doesn’t relieve the pain originated from a tooth infection. The tooth infection is inflammatory in nature, and cyclobenzaprine is a muscle relaxant. It benefits pain resulting from muscle spasms and is always given in combination with other painkillers.  

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